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世聯(lián)翻譯公司完成醫藥專(zhuān)業(yè)領(lǐng)域英文翻譯
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世聯(lián)翻譯公司完成醫藥專(zhuān)業(yè)領(lǐng)域英文翻譯
Exp Mol Pathol. 1990 Feb;52(1):98-108.Ultrastructural effects of Nifurtimox on rat adrenal cortex related to reductive biotransformation.de Castro CR, De Toranzo EG, Carbone M, Castro JA.SourceCentro de Investigaciones Toxicológicas (CEITOX) CITEFA/CONICET, Provincia de Buenos Aires, Argentina.AbstractNifurtimox (Nfx) (4(5-nitrofurfurylidene)amino)-3-methylthiomorpholine-1, 1-dioxide) is a drug used against Chagas' disease, a parasitic sickness afflicting several million Latin Americans. Nfx administration to Sprague-Dawley male rats (220-250 g) at a dose of 100 mg/kg caused pronounced alterations in the adrenal cortex involving the fasciculata and reticularis zones but which were not evident in the glomerulosa. Alterations observed involved mitochondria, nuclei, Golgi apparatus, and the endoplasmic reticulum but were more intense in the mitochondria. There is Nfx nitroreductase activity in the adrenal microsomal, mitochondrial, and cytosolic-rich fractions but most of it is in the mitochondrial-rich fraction. Activity in the first two fractions requires NADPH and that in the cytosol is only observed in the presence of hypoxanthine as substrate. Enzymatic activity in all fractions is inhibited by oxygen. CO does not inhibit mitochondrial Nfx nitroreductase and inhibits only 10% of the microsomal enzyme activity. Hypoxanthine-dependent cytosolic activity is inhibited by allopurinol. Present results suggest that Nfx is activated to damage-producing reactive metabolites by nitroreductive biotransformation in rat adrenal organelles. Mitochondrial and microsomal bioactivation would occur at the level of the flavoenzyme P-450 reductase rather than at P-450 itself, and cytosolic bioactivation would be mediated by xanthine oxidase. Epidemiological studies on adrenal function in patients undergoing Nfx treatment would be necessary to establish the potential toxicological relevance of these findings.PMID: 2106446 [PubMed - indexed for MEDLINE]Unitrans世聯(lián)翻譯公司在您身邊,離您近的翻譯公司,心貼心的專(zhuān)業(yè)服務(wù),專(zhuān)業(yè)的全球語(yǔ)言翻譯與信息解決方案供應商,專(zhuān)業(yè)翻譯機構品牌。無(wú)論在本地,國內還是海外,我們的專(zhuān)業(yè)、星級體貼服務(wù)，為您的事業(yè)加速！世聯(lián)翻譯公司在北京、上海、深圳等國際交往城市設有翻譯基地，業(yè)務(wù)覆蓋全國城市。每天有近百萬(wàn)字節的信息和貿易通過(guò)世聯(lián)走向全球！積累了大量政商用戶(hù)數據，翻譯人才庫數據，多語(yǔ)種語(yǔ)料庫大數據。世聯(lián)品牌和服務(wù)品質(zhì)已得到政務(wù)防務(wù)和國際組織、跨國公司和大中型企業(yè)等近萬(wàn)用戶(hù)的認可。 專(zhuān)業(yè)翻譯公司,北京翻譯公司,上海翻譯公司,英文翻譯,日文翻譯,韓語(yǔ)翻譯,翻譯公司排行榜,翻譯公司收費價(jià)格表,翻譯公司收費標準,翻譯公司北京,翻譯公司上海。
